submit news    HOME | FEEDBACK  


« NAVIGATION »
NEWS

- Bio/Medicine

- Chemicals

- Defense

- Drug Delivery

- Education

- Electronics

- Energy

- Events

- Grants

- Industry

- Investment

- Litigation

- Materials

- MEMS

- Nanofabrication

- Nanoparticles

- Nanotubes

- Optics

- Partnership

- Patent

- Products

- Quantum dots

- Research

- Smart Dust

- Software
COMPANIES
EVENTS

- Browse by Month

- Current Shows

- Previous Shows

- Submit Events
FEEDBACK
ADVERTISE
LINK TO US

« PARTNERS »
Become A Nanotechwire Partner

FEI Company

Veeco Instruments

Nano Science and Technology Institute

National Nanotechnology Initiative

Nanotechnology at Zyvex

Want to see your Company or Organization listed above? Become A Nanotechwire Partner Today - click here
« NEWSLETTER »



« SEARCH »







8/30/2009 10:05:18 AM
Nanoparticle-Based Gene Therapy Technique Could Fight Late-Stage Tumors

Nanoparticle delivery of diphtheria toxin-encoding DNA that expresses selectively in ovarian cancer cells reduced the burden of ovarian tumors in mice, and researchers expect that this therapy could be tested in humans with advanced ovarian cancer within 18 to 24 months, according to a report in Cancer Research. If additional tests are successful, these finding could lead to a new treatment for ovarian cancer, which now causes more than 15,000 deaths each year in the United States. Because it is usually diagnosed at a relatively late stage, ovarian cancer is one of the most deadly forms of the disease.

The new treatment, developed by Janet A. Sawicki, Ph.D., of the Lankenau Institute for Medical Research, and Daniel Anderson, Ph.D., of the Massachusetts Institute of Technology (MIT), delivers a gene that produces the diphtheria toxin, which kills cells by disrupting their ability to manufacture proteins. The toxin is normally produced by the bacterium Corynebacterium diphtheriae. The nanoparticle used to delivery the toxin-encoding DNA was developed by MIT’s Robert Langer, Ph.D., co-principal investigator of the MIT-Harvard Center of Cancer Nanotechnology Excellence.

In preclinical studies, the investigators found that the gene therapy treatment was equally as effective and in some cases more effective than the traditional chemotherapy combination of cisplatin and paclitaxel. Furthermore, it did not have the toxic side effects of chemotherapy because the gene is engineered to be overexpressed in ovarian cells but is inactive in other cell types.

To further ensure tumor-focused effects, the nanoparticles were administered by injection into the peritoneal cavity, which encases abdominal organs such as the stomach, liver, spleen, ovaries, and uterus. Ovarian cancer is known to initially spread throughout the peritoneal cavity, and current therapeutic approaches in humans include direct injection into the peritoneal space, thereby targeting the therapy to the ovaries and nearby tissues where tumors may have spread.

The new nanoparticles are made with positively charged, biodegradable polymers known as poly(beta-amino esters). When mixed together, these polymers can spontaneously assemble with DNA to form nanoparticles. The polymer-DNA nanoparticle can deliver functional DNA when injected into or near the targeted tissue. For several years, the MIT-Lankenau team has been developing these nanoparticles as an alternative to viruses, which are associated with safety risks. In addition to ovarian cancer, these nanoparticles have demonstrated potential for treatment of a variety of diseases, including prostate cancer and viral infection. In future studies, the team plans to examine the effectiveness of nanoparticle-delivered diphtheria toxin genes in other types of cancer, including brain, lung, and liver cancers.

This work, which was supported in part by the National Cancer Institute, is detailed in the paper “Nanoparticle-delivered suicide gene therapy effectively reduces ovarian tumor burden in mice.” An abstract is available at the journal’s Web site.

View abstract

Other Headlines from Massachusetts Institute of Technology ...
 - Toward faster transistors
 - New sensor developed by MIT chemical engineers can detect tiny traces of explosives
 - Catching cancer with carbon nanotubes
 - Seeing below the surface
 - Koch Institute for Integrative Cancer Research dedicated at MIT

Other Headlines from NCI Alliance for Nanotechnology in Cancer ...
 - Tekmira and the National Cancer Institute Publish Promising Data Demonstrating the Anti-Tumor Activity of a Novel Cancer Target
 - NCI Awards $1.7 Million to Cancer Specialist at Children’s Hospital Los Angeles
 - Nanoparticles Enhance Detection of Circulating Tumor Cells
 - Hand-held NMR Instrument Yields Rapid Analysis of Human Tumors
 - Biodegradable Biopolymer Nanoparticles Hold Promise for Twin Attack on Breast Cancer

More Nanoparticles Headlines ...
 - UI study: Carbon black nanoparticles activate immune cells, causing cell death
 - Nanoparticles help scientists harvest light with solar fuels
 - Non-toxic nanoparticles may someday be used to fight cancer
 - 'DNAsomes' can deliver multiple drugs or genetic therapy
 - Building From the Ground Up, Researchers Construct RNA Nanoparticles to Safely Deliver Long-Lasting Therapy to Cells


« Back To List »

« GET LISTED »
- submit company
- submit news
- submit events
- advertise here

« EVENTS »
- More Events


Copyright © 2014 Nanotechwire.com | Privacy Policy |