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4/17/2006 1:01:09 AM
Site-Selective Modification of Carbon Nanotubes

Carbon nanotubes have shown tremendous promise as key elements in ultrasensitive detectors of cancer-related markers and genes, and toward that end, investigators have developed a number of methods for attaching antibodies and other “detection” agents to the surface of carbon nanotubes. Now, researchers at Rensselaer Polytechnic Institute have developed a technique that allows them to attach molecules to just a few specific nanotubes within an array of thousands of nanotubes. This new method could speed the development of nanosensor arrays capable of detecting multiple cancer markers in human tissue or blood samples.

Reporting its work in the journal Advanced Materials, a research team headed by Ganapathiraman Ramanath, Ph.D., used a technique known as focused ion beam irradiation, followed by a mild chemical reaction, to functionalize carbon nanotubes at preselected locations within an array of nanotubes. The same technique can be used to functionalize an individual nanotube at a specific location along its length.

The key to this method is using ions of very high energy to create chemically reactive defects on a carbon nanotube. These defects then act as sites for anchoring detection reagents and other biomolecules using mild chemical reactions of the sort that do not damage biomolecules. By using focused ion beams to create the defects, the researchers were able to create reactive areas as small as 5 nanometers in width on the nanotube surface.

The investigators presented several examples in which they successfully modified nanotubes with useful detection agents. In one case, the researchers were able to attach gold nanoparticles to carbon nanotubes. In another example, the researchers demonstrated that they could attach a sensitive metal-containing enzyme to the nanotubes without damaging the protein in the process.

This work is detailed in a paper titled, “Site-selective functionalization of carbon nanotubes.” An abstract of this paper is available at the journal’s website.

Other Headlines from NCI Alliance for Nanotechnology in Cancer ...
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 - NCI Awards $1.7 Million to Cancer Specialist at Children’s Hospital Los Angeles
 - Nanoparticles Enhance Detection of Circulating Tumor Cells
 - Hand-held NMR Instrument Yields Rapid Analysis of Human Tumors
 - Biodegradable Biopolymer Nanoparticles Hold Promise for Twin Attack on Breast Cancer

Other Headlines from Rensselaer Polytechnic Institute ...
 - Nano Fit-ness: Helping Enzymes Stay Active and Keep in Shape
 - "Liquid Pistons" Could Drive New Advances in Camera Lenses and Drug Delivery
 - "Nanoscoops" Could Spark New Generation of Electric Automobile Batteries
 - Rensselaer Polytechnic Institute Professor Georges Belfort Wins Biochemical Engineering Award
 - Measuring the Temperature of Nanoparticles

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 - Bayer MaterialScience strengthens position in carbon nanotubes
 - New desalination process using carbon nanotubes
 - Ultra fast photodetectors out of carbon nanotubes

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